Take MAP® & the sky is the limit!

    ABOUT MAP Master Amino Acid Pattern®

    MAP Master Amino Acid Pattern® is a the most health preserving and nutritionally more effective substitute for dietary proteins.

    COMPOSITION

    MAP Master Amino Acid Pattern® provides a proprietary, unparalleled amino acids formula that contains a unique pattern of essential amino acids, described in U.S. Patent No. 5,132,113, such as L-Leucine, L-Valine, L-Isoleucine, L-Lysine HCl, L-Phenylalanine, L-Threonine, L-Methionine, L-Tryptophan, in a highly purified, free, crystalline form. Each tablet of MAP® contains only the active ingredient MAP® and contains no inactive ingredients or excipient.

    CLINICAL STUDIES

    Published comparative, double-blind, triple and quintuple crossover Net Nitrogen Utilization® (NNU®) clinical studies, performed in human subjects1-10 have shown that:

    • The use of MAP® provides a Body Protein Synthesis = 99% Net Nitrogen Utilization, per minute (BPS=99%NNU/ 23min). That is, the highest BPS=NNU/min, in comparison to any dietary protein, protein supplement or amino acid formula. By comparison dietary proteins, protein supplements or amino acids formulas provide a BPS = 16-32% NNU/180-360 min. That is a BPS, 24 to 96 times lower in comparison to MAP.
    • The use of MAP® releases only 1% nitrogen catabolites, namely, metabolic toxic waste. That is, the lowest amount of nitrogen catabolites, in comparison to any dietary protein, protein supplement or amino acid formula. By comparison, dietary proteins, protein supplements or amino acid formulas release between 68% to 84% nitrogen catabolites. That is, 68 to 84 times more nitrogen catabolites, namely metabolic toxic waste, in comparison to MAP®.

    This means that 99% of MAP®'s constituent amino acids followed the anabolic pathway, thus acting as precursor for body's protein synthesis (BPS), namely as “building blocks”. By comparison, dietary proteins only provide an average between 16 to 32% NNU®. These facts evidence that MAP® is significant more nutritious than dietary proteins. This has been confirmed by the fact that during the study, each subject body's nitrogen balance was maintained in equilibrium by taking MAP®, as a sole and total substitute for of dietary proteins, in a dosage of only 400 mg/kg/day, providing less than 2 kcal/day (1g MAP®= 0.04 kcal). The study results have also shown that 1% of MAP®'s constituent amino acids followed the catabolic pathway, thus releasing only 1% of nitrogen catabolites (NC) and energy. By comparison dietary proteins release between 68% to 84% nitrogen catabolites and energy. This fact evidences that the use of MAP® is more health preserving than that of dietary proteins, and provides the lowest amount of energy in comparison to any dietary protein.

    Figure 1. Dietary Protein Metabolism

    To illustrate: when a dietary protein is digested, it releases its constituent amino acids into the small intestine where they are absorbed. Then, those amino acids can follow either the anabolic pathway (build-up) or the catabolic pathway (breakdown) .

    Figure II. The Protein Metabolism Anabolic Pathway

    When dietary amino acids follow the anabolic pathway, they act as precursors for the body’s protein synthesis, to eventully become the body’s constituent proteins. Throughout the anabolic pathway, amino acids  do not release any nitrogen catabolites or energy.

    Figure III. The Protein Metabolism Catabolic Pathway

    On the other hand, when dietary amino acids follow the catabolic pathway, they act only as a source of energy and not as precursors of Body’s Proteins Synthesis (BPS). Throughout the catabolic pathway, amino acids do release nitrogen catabolites ( toxic metabolic residue) and energy.

    INDICATIONS AND USAGE

    The use of MAP® is recommended as the most health preserving and the most nutritious in substitution for dietary proteins.

    DOSAGE AND ADMINISTRATION

    MAP® should be orally administered, preferably with food. MAP® in a dosage of 400mg/kg*/day (*ideal weight) has been shown to be adequate as a sole and total substitute of dietary proteins to maintain the body’s nitrogen balance in equilibrium. To calculate the MAP® dosage necessary to substitute dietary proteins, apply the following:


    MAP® dosage = (Dietary Protein x 0.4) g


    For instance, to calculate the dosage of MAP® necessary to substitute 10 g of high biological value dietary proteins, proceed as follows:

    1. MAP® dosage = (Dietary Proteins x 0.4) g
    2. MAP® dosage = (10 x 0.4) g
    3. MAP® dosage = 4 g

    Therefore, 4 g (4 tablets) of MAP® provide a body’s protein synthesis (BPS) equivalent to that provided by at least 10 g of dietary protein with the highest biological value.

    If administering more than 10 tablets per day, increase dosage gradually. (Not more than 10 tablets should be administered within a two hour period.)

    OVERDOSAGE

    No adverse reactions have been reported.

    ADVERSE REACTIONS 

    No adverse reactions have been reported.

    INFORMATION

    MAP® is available in bottles of 120 tablets of 1,000 mg, for oral administration. Each tablet of MAP® (1g) contains only the active ingredient MAP®. MAP® contains no inactive ingredients.

    SCIENTIFIC REFERENCES RELATED TO MAP MASTER AMINO ACID PATTERN®


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    2. Lucà-Moretti M. Comparative study of subjects’ Net Nitrogen Utilization (NNU) while receiving SON, or egg protein or its protein amino acid formula. Advances in Therapy; 5:280-89, 1992.
    3. Lucà-Moretti M. Comparative study of subjects’ Net Nitrogen Utilization (NNU) while receiving bovine milk or soybean flour with or without SON nutrification. JIMHA; 1:43-54, 1992.
    4. Lucà-Moretti M. Comparative study of subjects’ Net Nitrogen Utilization (NNU) while receiving bovine milk or soybean flour with or without SON nutrification. Advances in Therapy; 5:290-301, 1992.
    5. Lucà-Moretti M., Grandi, A. The Malnutrition Treatment and Prevention Project. JIMHA; 2:20-26, 1993.
    6. Lucà-Moretti M., Grandi, A. Comparative Study of Subjects’ Weight Loss while receiving Very Low Calorie Diets consisting of SON, SON-Nutrified Dried Bovine Skim Milk, or Dried Bovine Skim milk provided in the required amounts to achieve Zero Nitrogen Balance. JIMHA; 2:39-48, 1993.
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    38. Lucà-Moretti, M., Grandi A., Lucà E., Mariani E., Vender G., Arrigotti E., Ferrario M., Rovelli E Results of taking Master Amino Acids Pattern® as a sole and total substitute of dietary proteins in an athlete during a desert crossing. Advances in Therapy; 4:203-210, 2003.
    39. Lucà-Moretti, M., Grandi A., Lucà E., Muratori G., Nofroni M.G., Mucci M.P., Gambetta P., Stimolo R., Drago P., Giudice G., Tamburlin N., Karbalay M., Valente C., Moras G. Master Amino Acids Pattern® as sole and total substitute for dietary proteins during a weight loss diet to achieve the body’s Nitrogen Balance equilibrium. Advances in Therapy; 5:270-281, 2003.
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